Anti-B2M Mouse Monoclonal Antibody (Biotin) [clone: C21.48A1]

Supplier: Biotium

BNCB0433-100 BNCB0433-500

75882-170EA 325.12 CAD

75882-170 75882-172

Anti-B2M Mouse Monoclonal Antibody (Biotin) [clone: C21.48A1]

Antibodies

The antibody recognizes the hidden determinant of β2-microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. β2-microglobulin is a 12 kDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkins lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. β2-microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Type: Primary
Antigen: B2M
Clonality: Monoclonal
Clone: Clone C21.48A1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human, Non-human primates

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