Anti-MALT1 Mouse Monoclonal Antibody (Biotin) [clone: MT1/410]

Supplier: Biotium

BNCB0410-100 BNCB0410-500

75959-706EA 325.12 CAD

75959-706 75959-708

Anti-MALT1 Mouse Monoclonal Antibody (Biotin) [clone: MT1/410]

Antibodies

Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.

Type: Primary
Antigen: MALT1
Clonality: Monoclonal
Clone: Clone MT1/410
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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