Anti-TIMP3 Rabbit Polyclonal Antibody (CF488A) [clone: Rabbit PAb]

Supplier: Biotium

BNC880408-100 BNC880408-500

75980-874EA 325.12 CAD

75980-874 75980-876

Anti-TIMP3 Rabbit Polyclonal Antibody (CF488A) [clone: Rabbit PAb]

Antibodies

TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: TIMP3
Clonality: Polyclonal
Clone: Clone Rabbit PAb
Conjugation: CF488A
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Cow, Dog, Horse, Human, Mouse, Rat

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