Anti-TIMP3 Rabbit Polyclonal Antibody (CF405S) [clone: Rabbit PAb]

Supplier: Biotium

BNC040408-100 BNC040408-500

75980-870EA 325.12 CAD

75980-870 75980-872

Anti-TIMP3 Rabbit Polyclonal Antibody (CF405S) [clone: Rabbit PAb]

Antibodies

TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: TIMP3
Clonality: Polyclonal
Clone: Clone Rabbit PAb
Conjugation: CF405S
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Cow, Dog, Horse, Human, Mouse, Rat

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