Anti-KRT77 & KRT76 Mouse Monoclonal Antibody (CF568) [clone: AE-1 / AE-3]

Supplier: Biotium

BNC680371-100 BNC680371-500
75910-338EA 325.12 CAD
75910-338 75910-340
Anti-KRT77 & KRT76 Mouse Monoclonal Antibody (CF568) [clone: AE-1 / AE-3]
Antibodies
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8); 56.5 kDa (CK10); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 40 kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Type: Primary
Antigen: KRT77 & KRT76
Clonality: Monoclonal
Clone: Clone AE-1 / AE-3
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Chicken, Cow, Dog, Human, Monkey, Mouse, Rabbit, Rat
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