Anti-CD53 Mouse Monoclonal Antibody [clone: 63-5A3]

Supplier: Biotium

BNUB0356-100 BNUB0356-500

75914-380EA 380.65 CAD

75914-380 75914-382

Anti-CD53 Mouse Monoclonal Antibody [clone: 63-5A3]

Antibodies

This antibody recognizes a protein of 33-55 kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.

Type: Primary
Antigen: CD53
Clonality: Monoclonal
Clone: Clone 63-5A3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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