Anti-CD53 Mouse Monoclonal Antibody (CF640R) [clone: 63-5A3]

Supplier: Biotium

BNC400356-100 BNC400356-500

75914-422EA 325.12 CAD

75914-422 75914-424

Anti-CD53 Mouse Monoclonal Antibody (CF640R) [clone: 63-5A3]

Antibodies

This antibody recognizes a protein of 33-55 kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: CD53
Clonality: Monoclonal
Clone: Clone 63-5A3
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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