Anti-HSPG2 Rat Monoclonal Antibody (Biotin) [clone: A7L6]

Supplier: Biotium

BNCB0315-100 BNCB0315-500

75981-188EA 325.12 CAD

75981-188 75981-190

Anti-HSPG2 Rat Monoclonal Antibody (Biotin) [clone: A7L6]

Antibodies

This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Type: Primary
Antigen: HSPG2
Clonality: Monoclonal
Clone: Clone A7L6
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2a, kappa
Reactivity: Cow, Fish, Human, Monkey, Mouse, Pig

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