Anti-KRT17 Mouse Monoclonal Antibody (CF640R) [clone: E3]

Supplier: Biotium

BNC400158-500 BNC400158-100
75916-326EA 900.17 CAD
75916-326 75917-036
Anti-KRT17 Mouse Monoclonal Antibody (CF640R) [clone: E3]
Antibodies
Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as an epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: KRT17
Clonality: Monoclonal
Clone: Clone E3
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Cow, Goat, Human, Pig, Rat
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