Anti-MAGEA1 Mouse Monoclonal Antibody (Biotin) [clone: MA454]

Supplier: Biotium

BNCB0008-100 BNCB0008-500

75957-236EA 325.12 CAD

75957-236 75957-238

Anti-MAGEA1 Mouse Monoclonal Antibody (Biotin) [clone: MA454]

Antibodies

This antibody recognizes a protein of 42-46 kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8 T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Type: Primary
Antigen: MAGEA1
Clonality: Monoclonal
Clone: Clone MA454
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Dog, Human, Rat

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