Pierce™ NeutrAvidin™ Protein, Thermo Scientific
Supplier: Thermo Scientific
Pierce™ NeutrAvidin™ Protein is a specially-prepared form of avidin biotin-binding protein that decreases background in biotin-binding.
- Near-neutral isoelectric point - pI = 6.3
- Nearly devoid of glycosylation - decreased possibility of lectin binding compared to native avidin
- No RYD recognition sequence - no known off-target binding domains like streptavidin
- Less expensive than streptavidin
NeutrAvidin Protein is deglycosylated native avidin from egg whites. Removal of the excess carbohydrate by an exclusive process yields a protein with a more neutral isoelectric point and less nonspecific binding properties. Purified NeutrAvidin Protein provides exceptional performance in western blot, ELISA, and IHC applications that require biotin-binding probes. Assay specificity, sensitivity, and signal-to-noise ratios with this protein are generally equivalent or better than with the significantly more expensive streptavidin. The specific activity for biotin-binding is approximately 14 µg/mg of protein, which is near the theoretical maximum activity.
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