GW806742X ≥95%

Supplier: ADIPOGEN CORP MS

SYN-1215-M005 SYN-1215-M010

102979-862EA 393.85 CAD

102979-862 102979-864

GW806742X ≥95%

GW806742X

Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited TSQ-induced death of mouse dermal fibroblasts by delaying MLKL translocation to the membrane. Appears therefore to be a valuable reagent to inhibit necroptosis. It also provides an important proof-of-principle that targeting catalytically-dead pseudoenzymes represents a feasible, emerging therapeutic avenue.

Formula: C₂₅H₂₂F₃N₇O₄S
Storage Temperature: Freezer

MDL Number: MFCD29036385
CAS Number: 579515-63-2

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO.

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