Anti-TCR beta Armenian Hamster Monoclonal Antibody (PE) [clone: H57-597]

Supplier: Tonbo Biosciences

Anti-TCR beta Armenian Hamster Monoclonal Antibody (PE) [clone: H57-597]

Anti-TCR beta Armenian Hamster Monoclonal Antibody (PE) [clone: H57-597]

50-5961-U025 50-5961-U100

75834-194EA 74.26 CAD

75834-194 75834-340

Anti-TCR beta Armenian Hamster Monoclonal Antibody (PE) [clone: H57-597]

Antibodies

The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.

The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.

Type: Primary
Antigen: TCR beta
Clonality: Monoclonal
Clone: H57-597
Conjugation: PE
Epitope:
Host: Armenian Hamster
Isotype: Armenian Hamster IgG
Reactivity: Mouse

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