AEBSF hydrochloride (4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride) ≥97% (by HPLC), Calbiochem®
Supplier: MilliporeSigma
Specific, irreversible inhibitor of serine proteases.
Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1 to 1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H₂O (Cat. No. 508436).
Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes.
Special Instructions: Following reconstitution, store in the refrigerator (4 °C). Aqueous stock solutions are stable for up to 2 months at 4 °C. Slight hydrolysis occurs at alkaline pH (8 to 9).
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