n-Dodecyl-β-D-Maltoside is especially useful for solubilizing membrane proteins to preserve their activity. Store below -20˚C.
- Lipid-like nonionic detergent
- Especially useful for isolating and stabilizing hydrophobic membrane proteins
- Preserves activity of membrane protein better than most of the detergents
- High-purity compound with low UV absorptivity
The water-soluble nonionic detergent is most often used for the isolation of hydrophobic membrane proteins
Like most detergents, n-Dodecyl-β-D-maltoside has dual hydrophobic/hydrophilic properties that facilitate lipid displacement and provide a lipid-like environment for membrane proteins. Studies suggest that the ability of these surfactants to preserve membrane protein structure stems in part from the reduced disruption of lipid:protein interactions where some of the natural lipid associations are maintained. While no detergent or set of conditions is optimal for all studies on membrane proteins, n-Dodecyl-β-D-maltoside has unique characteristics that have made it especially helpful in certain protein methods.
Multiple studies have shown that n-Dodecyl-β-D-maltoside is a gentle detergent that is often able to preserve protein activity better than many commonly used detergents, including NP-40, CHAPS and Octyl-β-glucoside.
Caution: For Research Use Only. Not for use in diagnostic procedures.
