This antibody is predicted to react with canine and mouse based on sequence homology. AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
Immunocytochemistry: 2 µg/ml, Immunofluorescence: 2 µg/ml, Immunohistochemistry: Assay Dependent, Western Blot: 0.1-0.3 µg/ml
Type: Primary
Antigen: AGR2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Goat
Isotype: IgG
Reactivity: Mouse, Rat, Human