Anti-PTPN1 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA515521

CAPIPA5-15521EA 3406.91 CAD

CAPIPA5-15521

Anti-PTPN1 Rabbit Polyclonal Antibody

Antibodies

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Recommended Dilutions: Western Blot: 1:1000

Type: Primary
Antigen: PTPN1 (protein tyrosine phosphatase, non-receptor type 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity:

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