Anti-E2F1 Rabbit Polyclonal Antibody

Supplier: Pierce Biotechnology

PA512914

CAPIPA5-12914EA 3258.01 CAD

CAPIPA5-12914

Anti-E2F1 Rabbit Polyclonal Antibody

Antibodies

E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Recommended Dilutions: Dot blot: 1:500

Type: Primary
Antigen: E2F1 (E2F transcription factor 1)
Clonality: polyclonal
Clone:
Conjugation: unconjugated
Epitope:
Host: Rabbit
Isotype: none
Reactivity: Human

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