Mouse Recombinant PDGF-AA (from E. coli)

Supplier: Peprotech

315-17-2UG 315-17-10UG 315-17-100UG 315-17-250UG 315-17-500UG 315-17-1MG
10780-756EA 229.35 CAD
10780-756 10780-758 10780-760 10780-762 10780-764 10780-766
Mouse Recombinant PDGF-AA (from E. coli)
Proteins and Peptides

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two α chains (250 total amino acids).


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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