Mouse Recombinant IL-21 (from E. coli)

Supplier: Peprotech

210-21-2UG 210-21-10UG 210-21-50UG 210-21-100UG 210-21-250UG 210-21-500UG 210-21-1MG
10780-018EA 223.76 CAD
10780-018 10780-020 10780-022 10780-024 10780-026 10780-028 10780-030
Mouse Recombinant IL-21 (from E. coli)
Proteins and Peptides

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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SPECIFICATIONS

Protein/peptide name IL-21
Environmentally Preferable
Protein synonyms Za11|Interleukin-21
Protein/peptide type Recombinant
Protein Function Cytokines and Growth Factors
Species Mouse
Source E. coli
Conjugation Unconjugated
Gene ID 60505 Q9ES17
Sequence MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS
Protease-free Y
Endotoxin level Low
Endotoxin content >0.1 ng/μg
Biological activity Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity 0.98
Form Lyophilized
Formulation Formulation can vary. Please refer to product CoA for information.
Molecular weight 15 kDa
Reconstitution instructions Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions Store at –20 °C prior to reconstitution.
Shipping temperature Ambient

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