Human Recombinant sDLL-4 (from HEK293 Cells)

Supplier: Peprotech

140-07-5UG 140-07-25UG 140-07-100UG 140-07-250UG 140-07-500UG 140-07-1MG

10779-402EA 221.44 CAD

10779-402 10779-404 10779-406 10779-408 10779-410 10779-412

Human Recombinant sDLL-4 (from HEK293 Cells)

Proteins and Peptides

Human sDLL-4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL-4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL-4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL-4 expression has been implicated in the vascular development of certain tumors. The human DLL-4 gene consists of a 503 amino acid extracellular domain with one DSL domain, eight EGF-like repeats, a 21 a.a. transmembrane domain, and a 135 a.a. cytoplasmic domain. Recombinant Human sDLL-4 is a 54.3 kDa glycoprotein containing 498 amino acid residues.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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