Human Recombinant Wnt-1 (from E. coli)

Supplier: Peprotech

120-17-50UG 120-17-100UG 120-17-250UG 120-17-500UG 120-17-1MG

10779-152EA 1682.54 CAD

10779-152 10779-154 10779-156 10779-158 10779-160

Human Recombinant Wnt-1 (from E. coli)

Proteins and Peptides

Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors, and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. Wnt signaling induces and maintains the transformed phenotype, and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis, and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant Human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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