Human;Mouse;Rat Recombinant BMP-2 (from E. coli)

Supplier: Peprotech

120-02-2UG 120-02-10UG 120-02-50UG 120-02-100UG 120-02-250UG 120-02-500UG 120-02-1MG
10779-084EA 241.79 CAD
10779-084 10779-086 10779-088 10779-090 10779-092 10779-094 10779-096
Human;Mouse;Rat Recombinant BMP-2 (from E. coli)
Proteins and Peptides

BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis, and is expressed in a variety of tissues, including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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SPECIFICATIONS

Protein/peptide name BMP-2
Environmentally Preferable
Protein synonyms Bone Morphogenetic Protein-2|BMP-2A
Protein/peptide type Recombinant
Protein Function Cytokines and Growth Factors
Species Human,Rat,Mouse
Source E. coli
Conjugation Unconjugated
Gene ID 650 P12643
Sequence MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Protease-free Y
Endotoxin level Low
Endotoxin content >0.1 ng/μg
Biological activity Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity 0.98
Form Lyophilized
Formulation Formulation can vary. Please refer to product CoA for information.
Molecular weight 26 kDa
Reconstitution instructions Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions Store at –20 °C prior to reconstitution.
Shipping temperature Ambient

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