Human Recombinant GDF-5 (from E. coli)

Supplier: Peprotech

120-01-10UG 120-01-50UG 120-01-100UG 120-01-250UG 120-01-500UG 120-01-1MG

10779-072EA 209.84 CAD

10779-072 10779-074 10779-076 10779-078 10779-080 10779-082

Human Recombinant GDF-5 (from E. coli)

Proteins and Peptides

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human GDF-5 (BMP-14/CDMP-1) is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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