Mouse Recombinant TNF-alpha (from E. coli)

Supplier: Peprotech

AF-315-01A-5UG AF-315-01A-20UG AF-315-01A-50UG AF-315-01A-100UG AF-315-01A-250UG AF-315-01A-500UG AF-315-01A-1MG
10778-784EA 288.26 CAD
10778-784 10778-786 10778-788 10778-790 10778-792 10778-794 10778-796
Mouse Recombinant TNF-alpha (from E. coli)
Proteins and Peptides

TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-α demonstrate significant cross-species reactivity. TNF-α exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-α transmembrane protein is proteolytically cleaved to yield a soluble, biologically active, 17 kDa TNF-α, which forms a non-covalently linked homotrimer in solution. Recombinant Murine TNF-α is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.


  • Animal-free


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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SPECIFICATIONS

Protein/peptide name TNF-alpha
Environmentally Preferable
Protein synonyms Cytotoxin|Differentiation-Inducing Factor (DIF)|Necrosin|TNFSF1A|TNFSF2|Tumor Necrosis Factor-α|Cachectin
Protein/peptide type Recombinant
Protein Function Cytokines and Growth Factors
Species Mouse
Source E. coli
Conjugation Unconjugated
Gene ID 21926 P06804
Sequence MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL
Protease-free Y
Animal-free Y
Endotoxin level Low
Endotoxin content >0.1 ng/μg
Biological activity Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity 0.98
Form Lyophilized
Formulation Formulation can vary. Please refer to product CoA for information.
Molecular weight 17.3 kDa
Reconstitution instructions Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions Store at –20 °C prior to reconstitution.
Shipping temperature Ambient

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