Human Recombinant IL-21 (from E. coli)

Supplier: Peprotech

AF-200-21-2UG AF-200-21-10UG AF-200-21-100UG AF-200-21-250UG AF-200-21-500UG AF-200-21-1MG

10778-370EA 285.76 CAD

10778-370 10778-372 10778-374 10778-376 10778-378 10778-380

Human Recombinant IL-21 (from E. coli)

Proteins and Peptides

IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.

Animal-free

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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