Human Recombinant IGF-BP4 (from (BTI-Tn-5B1-4) Hi-5 Insect cells)

Supplier: Peprotech

350-05B-5UG 350-05B-20UG 350-05B-100UG 350-05B-250UG 350-05B-500UG 350-05B-1MG

10774-428EA 221.03 CAD

10774-428 10774-430 10774-432 10774-434 10774-436 10774-438

Human Recombinant IGF-BP4 (from (BTI-Tn-5B1-4) Hi-5 Insect cells)

Proteins and Peptides

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF-independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells. Recombinant Human IGF-BP4 is a 25.7 kDa protein consisting of 237 amino acid residues including, the IGF-BP domain and thyroglobulin type-I domain.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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