Human Recombinant TNF-alpha (from E. coli)

Supplier: Peprotech

300-01A-10UG 300-01A-50UG 300-01A-100UG 300-01A-250UG 300-01A-500UG 300-01A-1MG

10773-450EA 240.24 CAD

10773-450 10773-452 10773-454 10773-456 10773-458 10773-460

Human Recombinant TNF-alpha (from E. coli)

Proteins and Peptides

TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-α demonstrate significant cross-species reactivity. TNF-α exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-α transmembrane protein is proteolytically cleaved to yield a soluble, biologically active, 17 kDa TNF-α, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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