Mouse Recombinant GDNF (from E. coli)

Supplier: Peprotech

AF-450-44-10UG AF-450-44-100UG AF-450-44-250UG AF-450-44-500UG AF-450-44-1MG
10771-848EA 652.07 CAD
10771-848 10771-850 10771-852 10771-854 10771-856
Mouse Recombinant GDNF (from E. coli)
Proteins and Peptides

GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer consisting of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Murine GDNF is 30.2 kDa.


  • Animal-free


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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SPECIFICATIONS

Protein/peptide name GDNF
Environmentally Preferable
Protein synonyms Glial-Derived Neurotrophic Factor|ATF (Astrocyte-derived Trophic Factor)
Protein/peptide type Recombinant
Protein Function Cytokines and Growth Factors
Species Mouse
Source E. coli
Conjugation Unconjugated
Gene ID 14573 P48540
Sequence MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Protease-free Y
Animal-free Y
Endotoxin level Low
Endotoxin content >0.1 ng/μg
Biological activity Biological Activity tests can vary. Please refer to the Product CoA for information.
Purity 0.98
Form Lyophilized
Formulation Formulation can vary. Please refer to product CoA for information.
Molecular weight 30.2 kDa
Reconstitution instructions Reconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditions Store at –20 °C prior to reconstitution.
Shipping temperature Ambient

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