Mouse Recombinant APRIL (from E. coli)

Supplier: Peprotech

315-13-5UG 315-13-20UG 315-13-100UG 315-13-250UG 315-13-500UG 315-13-1MG

10770-938EA 209.84 CAD

10770-938 10770-940 10770-942 10770-944 10770-946 10770-948

Mouse Recombinant APRIL (from E. coli)

Proteins and Peptides

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of the colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, competes for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines, including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF-like receptor binding of the APRIL precursor. Recombinant Murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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