Human Recombinant sFas (from CHO Cells)

Supplier: Peprotech

310-03H-10UG 310-03H-100UG 310-03H-250UG 310-03H-500UG 310-03H-1MG

10770-784EA 537.11 CAD

10770-784 10770-786 10770-788 10770-790 10770-792

Human Recombinant sFas (from CHO Cells)

Proteins and Peptides

Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activated B cells, which leads to down-regulation of the immune response. The mechanism of Fas-induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD, followed by processing of the pro-enzyme into active forms. These active caspases then cleave various cellular substrates, leading to the eventual cell death. Both human and murine sFasL are fully active on human and murine cells. Recombinant Human sFas Ligand is a 17.9 kDa protein comprising the TNF-homologous region of FasL and contains an 8-residue N-terminal His-Tag.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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