Human Recombinant Heregulinbeta-1 (from E. coli)

Supplier: Peprotech

100-03-10UG 100-03-50UG 100-03-100UG 100-03-250UG 100-03-500UG 100-03-1MG

10770-630EA 223.16 CAD

10770-630 10770-632 10770-634 10770-636 10770-638 10770-640

Human Recombinant Heregulinbeta-1 (from E. coli)

Proteins and Peptides

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4).

Recombinant Human Heregulinβ-1 is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues)

To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF).

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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