Anti-IL2RA Rat Monoclonal Antibody (Biotin) [clone: PC61.5]

Supplier: Tonbo Biosciences

30-0251-U025 30-0251-U100 30-0251-U500

10002-190EA 42.66 CAD

10002-190 10002-192 10002-194

Anti-IL2RA Rat Monoclonal Antibody (Biotin) [clone: PC61.5]

Antibodies

The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used to distinguish Treg cells from na�ve or conventional T cells which are CD25-. This clone has also been reported for depletion of Treg cells in vivo (use format suitable for functional assays).

Type: Primary
Antigen: IL2RA
Clonality: Monoclonal
Clone: PC61.5
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG1 lambda
Reactivity: Mouse

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