Anti-ProBDNF Sheep Polyclonal Antibody

Supplier: Biosensis

Western blot analysis of proBDNF on DRG homogenate. lane 1: brain; lane 2: DRG. The antibody recognises monomer and dimer of the recombinant proBDNF.

Anti-ProBDNF Sheep Polyclonal Antibody

Immunofluorescence analysis of proBDNF expression in human SHSY-5Y cells. Fixed (4% formaldehyde), permeabilized, and blocked (10% normal horse serum, 0.1% Triton X100) cells were incubated with proBDNF antibody (1:1000, red). Cell nuclei were stained with Hoechst dye (blue). Magnification: 100x.

Separation and detection of proBDNF in conditioned 293 cell culture medium (Lanes 1 and 3, 50 ng/lane) and purified mature BDNF (Lanes 2 and 4, 50 ng/lane) by reduced SDS-PAGE and western blotting.

Western blot analysis of proBDNF on DRG homogenate. lane 1: brain; lane 2: DRG. The antibody recognises monomer and dimer of the recombinant proBDNF.

Anti-ProBDNF Sheep Polyclonal Antibody

Immunofluorescence analysis of proBDNF expression in human SHSY-5Y cells. Fixed (4% formaldehyde), permeabilized, and blocked (10% normal horse serum, 0.1% Triton X100) cells were incubated with proBDNF antibody (1:1000, red). Cell nuclei were stained with Hoechst dye (blue). Magnification: 100x.

Separation and detection of proBDNF in conditioned 293 cell culture medium (Lanes 1 and 3, 50 ng/lane) and purified mature BDNF (Lanes 2 and 4, 50 ng/lane) by reduced SDS-PAGE and western blotting.

S-079-100

10782-948EA 516.66 CAD

10782-948

Anti-ProBDNF Sheep Polyclonal Antibody

Antibodies

Brain derived neurotrophic factor (BDNF) is synthesized as a precursor (proBDNF) which may be released and have physiological functions to cause cell death. It binds neurotrophin receptor p75 and sortilin and may also be important for the development of nervous system. proBDNF is synthesized in neurons and glia (eg., microglia), transported anterogradely and retrogradely and may be released in an activity dependent manner. This antibody is raised in sheep to detect the prodomain of BDNF and not the mature peptide.

Confirmed to react with purified human proBDNF, crossreact with mouse and rat proBDNF
Application Information:
ELISA, Western Blot, biological neutralization of proBDNF. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: ProBDNF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: [delete]
Host: Sheep
Isotype: IgG
Reactivity: Human, Mouse, Rat

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