[6]-Gingerol ≥95% (by HPLC) Zingiber officinale, Sigma-Aldrich®

Supplier: MilliporeSigma

Packaged under inert gas.

345868-5MG

CA80512-708EA 642.12 CAD

CA80512-708

[6]-Gingerol ≥95% (by HPLC) Zingiber officinale, Sigma-Aldrich®

[6]-Gingerol

An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1).

Phytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50 = 4 µM).

Formula: C₁₇H₂₆O₄
Storage Temperature: Freezer

MDL Number: MFCD00210507
CAS Number: 23513-14-6

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