Anti-CTLA4 Armenian Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: UC10-4F10-11]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with FITC Anti-Mouse CD4 (35-0041) followed by intracellular staining with 0.06 ug APC Anti-Mouse CD152 (20-1522) (right) or 0.06 ug APC Armenian Hamster isotype control (left).

C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with FITC Anti-Mouse CD4 (35-0041) followed by intracellular staining with 0.06 ug APC Anti-Mouse CD152 (20-1522) (right) or 0.06 ug APC Armenian Hamster isotype control (left).

20-1522-U025 20-1522-U100

10050-586EA 110.6 CAD

10050-586 10050-588

Anti-CTLA4 Armenian Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: UC10-4F10-11]

Antibodies

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Type: Primary
Antigen: CTLA4
Clonality: Monoclonal
Clone: UC10-4F10-11
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Armenian Hamster
Isotype:
Reactivity:

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