Anti-IL17RA Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: A7R34]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were stained with APC Anti-Mouse CD3 and 0.25 ug PE Anti-Mouse CD127 (50-1271) (right panel) or 0.25 ug PE Rat IgG2a isotype control (left panel).

C57Bl/6 splenocytes were stained with APC Anti-Mouse CD3 and 0.25 ug PE Anti-Mouse CD127 (50-1271) (right panel) or 0.25 ug PE Rat IgG2a isotype control (left panel).

50-1271-U025 50-1271-U100

10051-298EA 75.84 CAD

10051-298 10051-300

Anti-IL17RA Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: A7R34]

Antibodies

The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.

The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

Type: Primary
Antigen: IL17RA
Clonality: Monoclonal
Clone: A7R34
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

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