Anti-CSF1R Rat Antibody (PE (Phycoerythrin)) [clone: AFS98]

Supplier: Tonbo Biosciences

C57Bl/6 peripheral blood cells were stained with APC Anti-Mouse CD11b (20-0112) and 0.125 ug PE Anti-Mouse CD115 (50-1152) (right panel) or 0.125 ug PE Rat IgG2a (left panel).

C57Bl/6 peripheral blood cells were stained with APC Anti-Mouse CD11b (20-0112) and 0.125 ug PE Anti-Mouse CD115 (50-1152) (right panel) or 0.125 ug PE Rat IgG2a (left panel).

50-1152-U025 50-1152-U100

10141-202EA 107.44 CAD

10141-202 10141-204

Anti-CSF1R Rat Antibody (PE (Phycoerythrin)) [clone: AFS98]

Antibodies

The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.

The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor (use format appropriate for functional assays).

Type: Primary
Antigen: CSF1R
Clonality: 0
Clone: AFS98
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rat
Isotype:
Reactivity:

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