Anti-CD86 Rat Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: GL-1 (GL1)]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were unstimulated (left panel) or stimulated for 3 days with LPS (right panel) and stained with 0.125 ug FITC Anti-Mouse CD86 (35-0862) (solid line) or 0.125 ug FITC Rat IgG2a isotype control (dashed line).

C57Bl/6 splenocytes were unstimulated (left panel) or stimulated for 3 days with LPS (right panel) and stained with 0.125 ug FITC Anti-Mouse CD86 (35-0862) (solid line) or 0.125 ug FITC Rat IgG2a isotype control (dashed line).

35-0862-U025 35-0862-U100 35-0862-U500

10050-948EA 56.88 CAD

10050-948 10050-950 10050-952

Anti-CD86 Rat Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: GL-1 (GL1)]

Antibodies

The GL-1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

The GL-1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.

Type: Primary
Antigen: CD86
Clonality: Monoclonal
Clone: GL-1 (GL1)
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity:

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