Anti-CD8A Rat Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: 2.43]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were stained with 0.125 ug PerCP-Cy5.5 Anti-Mouse CD8a (65-1886) (solid line) or 0.125 ug PerCP-Cy5.5 Rat IgG2b isotype control (dashed line).

C57Bl/6 splenocytes were stained with 0.125 ug PerCP-Cy5.5 Anti-Mouse CD8a (65-1886) (solid line) or 0.125 ug PerCP-Cy5.5 Rat IgG2b isotype control (dashed line).

65-1886-U025 65-1886-U100

10051-604EA 135.88 CAD

10051-604 10051-606

Anti-CD8A Rat Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: 2.43]

Antibodies

The 2.43 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.

The 2.43 antibody is widely used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Type: Primary
Antigen: CD8A
Clonality: Monoclonal
Clone: 2.43
Conjugation: PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity:

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