Anti-IL4 Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: 11B11]

Supplier: Tonbo Biosciences

Mouse lymphoid cells were stimulated in the presence of a protein transport inhibitor. Cells were then fixed, permeabilized, stained with FITC Anti-Mouse CD4 (35-0041) and intracellularly with 0.5 ug APC Anti-Mouse IL-4 (20-7041) (right panel) or 0.5 ug APC Rat IgG1 (left panel).

Mouse lymphoid cells were stimulated in the presence of a protein transport inhibitor. Cells were then fixed, permeabilized, stained with FITC Anti-Mouse CD4 (35-0041) and intracellularly with 0.5 ug APC Anti-Mouse IL-4 (20-7041) (right panel) or 0.5 ug APC Rat IgG1 (left panel).

20-7041-U025 20-7041-U100

10050-658EA 93.22 CAD

10050-658 10050-660

Anti-IL4 Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: 11B11]

Antibodies

The 11B11 antibody binds to mouse Interleukin-4 (IL-4), a 14 kDa cytokine that is largely secreted by activated T cells of the Th2 subset, and to some degree by NKT and mast cells. This cytokine acts as a stimulatory factor for B cells, inducing their proliferation and differentiation, as well as playing a role in immunoglobulin class-switching. IL-4 may also provide autocrine stimulation for T cells, and affect the function of antigen presenting cells such as macrophages and dendritic cells. IL-4 can bind and signal via three cell surface receptor types: CD124 by itself, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex).

The 11B11 antibody is widely used for detection of intracellular levels of IL-4 protein by flow cytometry, as well as for analysis of soluble cytokine as measured by ELISA, and in functional assays to neutralization cytokine-receptor interactions. Please choose the appropriate format for each application.

Type: Primary
Antigen: IL4
Clonality: Monoclonal
Clone: 11B11
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG1
Reactivity: Mouse

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