Anti-CD4 Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: GK1.5]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were stained with 0.06 ug APC Anti-Mouse CD4 (20-0041) (solid line) or 0.06 ug APC Rat IgG2b isotype control (dashed line).

C57Bl/6 splenocytes were stained with 0.06 ug APC Anti-Mouse CD4 (20-0041) (solid line) or 0.06 ug APC Rat IgG2b isotype control (dashed line).

20-0041-U025 20-0041-U100

10140-990EA 64.78 CAD

10140-990 10140-992

Anti-CD4 Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: GK1.5]

Antibodies

The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will “compete” for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

Type: Primary
Antigen: CD4
Clonality: Monoclonal
Clone: GK1.5
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity:

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