Anti-CD8A Rat Monoclonal Antibody (violetFluor® 450) [clone: 53-6.7]

Supplier: Tonbo Biosciences

C57Bl/6 splenocytes were stained with 0.25 ug violetFluor 450 Anti-Mouse CD8a (75-0081) (solid line) or 0.25 ug violetFluor 450 Rat IgG2a isotype control (dashed line).

C57Bl/6 splenocytes were stained with 0.25 ug violetFluor 450 Anti-Mouse CD8a (75-0081) (solid line) or 0.25 ug violetFluor 450 Rat IgG2a isotype control (dashed line).

75-0081-U025 75-0081-U100

10051-776EA 113.76 CAD

10051-776 10051-778

Anti-CD8A Rat Monoclonal Antibody (violetFluor® 450) [clone: 53-6.7]

Antibodies

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Type: Primary
Antigen: CD8A
Clonality: Monoclonal
Clone: 53-6.7
Conjugation: violetFluor® 450
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity:

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