G(5')ppp(5')A RNA Cap Structure Analog, New England Biolabs

Supplier: New England Biolabs (NEB)

G(5')ppp(5')A RNA Cap Structure Analog - 1 umol

G(5')ppp(5')A RNA Cap Structure Analog - 1 umol

S1406L S1406S

CA101228-110EA 983 CAD

CA101228-110 CA101228-112

G(5')ppp(5')A RNA Cap Structure Analog, New England Biolabs

Nucleic Acid Reagents Nucleic Acid Modification and Labelling

The 5´terminal m7G cap present on most eukaryotic mRNAs promotes translation in vitro at the initiation level.

For most RNAs, elimination of the cap structure causes a loss of stability, especially against exonuclease degradation, and a decrease in the formation of the initiation complex of mRNAs for protein synthesis. Certain prokaryotic mRNAs containing a 5´ terminal cap structure are translated as efficiently as or more efficiently than eukaryotic mRNAs in a eukaryotic cell-free protein synthesizing system. Also a cap requirement has been observed for splicing eukaryotic substrate RNAs. A method using E. coli RNA Polymerase primed with m7G(5´)ppp(5´)G or m7G(5´)ppp(5´)A for an efficient in vitro synthesis of capped RNAs has been developed by Contreas. Larger amounts of capped RNAs are produced by transcription systems using SP6 RNA polymerase primed with m7G(5´)ppp(5´)G.

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