Anti-HMOX1 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
SPA-896D ADI-SPA-896-J ADI-SPA-896-D SPA-896F ADI-SPA-896-F
CA89106-602EA 358 CAD
CA89106-602 89106-604 89106-602 95040-518 CA89106-604
Anti-HMOX1 Rabbit Polyclonal Antibody
Antibodies
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

  • For Immunoprecipitation, Western Blot

Recognizes human, mouse, rat, dog, hamster, monkey and rabbit HO-1. Detects a band of ~32kDa by Western blot.

Type: Primary
Antigen: HMOX1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
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