Anti-HSPA8 Rat Monoclonal Antibody (Biotin)

Supplier: Enzo Life Sciences

Anti-HSPA8 Rat Monoclonal Antibody (Biotin)

Anti-HSPA8 Rat Monoclonal Antibody (Biotin)

SPA-815BD ADI-SPA-815B-D ADI-SPA-815B-F SPA-815BF

CA200062-708EA 904 CAD

200062-708 CA200062-708 CA200062-706 200062-706

Anti-HSPA8 Rat Monoclonal Antibody (Biotin)

Antibodies

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

For ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, EM

Recognizes human, mouse, rat, bovine, dog, chicken, guinea pig, hamster, monkey, pig, rabbit and sheep HSC70 (HSP73). Detects a band of ~73kDa by Western blot.

Type: Primary
Antigen: HSPA8
Clonality: Monoclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity: Human

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