Anti-HSP70 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Anti-HSP70 Rabbit Polyclonal Antibody

Anti-HSP70 Rabbit Polyclonal Antibody

SPA-811F ADI-SPA-811-F SPA-811D ADI-SPA-811-D

CA200062-696EA 743 CAD

CA200062-696 200062-694 CA200062-694 200062-696

Anti-HSP70 Rabbit Polyclonal Antibody

Antibodies

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

For Immunoprecipitation, Western Blot

Recognizes human, mouse, rat, bovine, beluga, dog, hamster, monkey, pig and sheep HSP70 (HSP72). Detects a band of ~70kDa by Western blot.

Type: Primary
Antigen: HSP70
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human

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