Anti-HSP70 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Enzo Life Sciences

Anti-HSP70 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))

Anti-HSP70 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))

SPA-810FID SPA-810FIF

CA95043-830EA 469.26 CAD

CA95043-830 CA95043-832

Anti-HSP70 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))

Antibodies

The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Recognizes human, mouse, rat, bovine, dog, chicken, Drosophila, fish, guinea pig, hamster, monkey, pig, rabbit and sheep HSP70 (HSP72). Detects a band of ~70kDa by Western blot.

Type: Primary
Antigen: HSP70
Clonality: Monoclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human

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