Anti-HSP70 Mouse Monoclonal Antibody (AP (Alkaline Phosphatase))

Supplier: Enzo Life Sciences

Anti-HSP70 Mouse Monoclonal Antibody (AP (Alkaline Phosphatase))

Anti-HSP70 Mouse Monoclonal Antibody (AP (Alkaline Phosphatase))

SPA-810APD SPA-810APF

CA200062-678EA 489.8 CAD

CA200062-678 CA200062-680

Anti-HSP70 Mouse Monoclonal Antibody (AP (Alkaline Phosphatase))

Antibodies

The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

For ELISA, Flow Cytometry, Western Blot

Recognizes human, mouse, rat, bovine, dog, chicken, fish, and teal HSP70 (HSP72).

Type: Primary
Antigen: HSP70
Clonality: Monoclonal
Clone:
Conjugation: AP (Alkaline Phosphatase)
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human

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