Anti-HSP25 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Anti-HSP25 Rabbit Polyclonal Antibody

Anti-HSP25 Rabbit Polyclonal Antibody

SPA-523D SPA-523F

CA200062-562EA 328.64 CAD

CA200062-562 CA200062-564

Anti-HSP25 Rabbit Polyclonal Antibody

Antibodies

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

For Immunohistochemistry, Western Blot

Recognizes human, rat, bovine, guinea pig and monkey HSP27. Detects a band of ~27kDa by Western blot.

Type: Primary
Antigen: HSP25
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Rat, Monkey, Bovine, Guinea Pig

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